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Xarelto Side Effect: Abnormal Liver Function

The liver is the heaviest organ of the body and the largest of all the internal organs. It is also one of the hardest working organs, performing several functions essential to life. Under doctor’s prescription, millions of Americans are currently taking the anti-coagulant medication, Xarelto, to help reduce the risk of blood clots, deep vein thrombosis, and pulmonary embolism. Unfortunately, case studies have shown that, among several other severe side effects, Xarelto can cause abnormal liver function in patients who take it.

If you or your loved one has suffered abnormal liver function or any other severe side effect of Xarelto, it is in your best interests to speak with a pharmaceutical litigation lawyer as soon as possible. Our practice at Farah & Farah is here to represent individuals who have been harmed by dangerous drugs and devices. We are currently investigating Xarelto cases nationwide. Our Xarelto abnormal liver function lawyers can tell you if you have a case against the manufacturer, and what damages you may be entitled to claim.

Functions of the Liver

The liver is located in the upper right part of the belly under the ribs. It weights approximately 1.5 kg (roughly 3.3 lbs). The liver performs a number of vital functions of the body, including:

  • Converting carbohydrates into glucose for energy;
  • Converting glucose into glycogen for storage;
  • Converting glycogen back into glucose when blood sugar levels drop;
  • Producing bile to be stored in the gall bladder and used to break down dietary fats;
  • Bile produced in the liver is also used to absorb fat soluble vitamins A, D, E, and K;
  • Producing body proteins, including hormones, from amino acids (from protein) that are sent to the liver;
  • Changing ammonia (a toxic byproduct of protein metabolism) into urea to be excreted in the urine; and
  • Filtering medications and drugs and neutralizing or converting them to other forms with special enzymes.

Blood coming from the digestive system must filter through the liver before it goes travels to the rest of the body. This hard-working organ handles the functions of processing nutrients, removing toxins from the body, and regulating the body’s metabolism. Damage to the liver can interfere with these important functions, with an adverse effect on general health.

Fortunately, the liver is very resilient and, in many cases, recovers on its own from inflammation, without the need of medical attention. However, a range of severe diseases and conditions could prevent this vital organ from performing optimally, including toxic damage from dangerous drugs.

Case Studies Show Xarelto Can Cause Liver Injury

According to an article on MPR, case studies reported in Journal of the American Medical Association (JAMA) raise questions regarding the safety of Xarelto, and particularly the damage it can cause to the liver. In the two case studies reported, both patients suffered severe liver injury during treatment with rivaroxaban (Xarelto).

One case study concerned a 52-year old man who was taking 10 mg of Xarelto each day to prevent deep vein thrombosis (blood clots in the legs or pelvic region) following surgery for a fractured tibia (inner leg bone below the knee). The patient developed severe lobular hepatitis (abrupt onset liver inflammation) consistent with drug-related liver injury. The patient stopped taking Xarelto and recovered from the liver disease after 14 days off the drug.

Another case study concerned a 73-year-old woman who suffered mixed liver injury from a 10 mg daily dosage of Xarelto, prescribed to prevent deep vein thrombosis after knee-replacement surgery. After the liver injury was discovered, the patient stopped taking Xarelto, but continued her other medications. This woman’s bilirubin and enzyme levels returned to normal 14 days after Xarelto was discontinued.

The authors of the MPR article warn readers that treatment with rivaroxaban (Xarelto) may be associated with severe liver injury. They state that physicians and patients should be made aware of this potentially severe adverse drug reaction, and suggest that the label should be amended to include this warning.

Xarelto Abnormal Liver Function Lawyers

Drug manufacturers have a responsibility to perform sufficient testing on their products before they release the drug onto the market. When they fail to so and their drugs cause serious harm, injured parties may be entitled to hold them accountable in a court of law.

Our knowledgeable pharmaceutical litigation attorneys at Farah & Farah are currently investigating Xarelto cases nationwide. If you or your loved one has suffered serious injuries from Xarelto, call us at (800) 533-3555. We are happy to provide a free case consultation with absolutely no obligation.


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Who We Are

The pharmaceutical litigation attorneys at Farah & Farah go after negligent corporations that put unsuspecting consumers in harm's way. Pharmaceutical companies not only have a duty to manufacture drugs that are safe, but they also have the obligation to warn consumers regarding dangerous side effects that can be caused by these drugs.

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